Title : Association between lung cancer and prostate cancer, 3 studied cases, short literature review

Background: The association of lung cancer with prostate cancer is little studied. In the Medscape site we do not have any reference to this association.

Material and method: We have collected data from 3 concrete cases regarding this association and we evaluated their characteristics. On the other hand, we did a literature review trying to do a review related to the particularities of the patients that were based on articles recommended by artificial intelligence (AI). We did not refer to possible genetic determinations, but from the current data, identical genetic modifications for these two types of cancer have not been investigated.

Results: We followed 10 articles selected by AI regarding the association of lung cancer (LC) with prostate cancer (PC). From the analysis of these studies and case presentations we drew several conclusions. Thus, from the articles studied, it emerges that this association is rare. Most authors studied pulmonary metastases of PC and not the association of LC with PC. The articles studied mainly present the metachronous association of PC cancer with (Small Cell Lung Cancer) SCLC, while our case series was represented by cases with Non Small Cell Lung Cancer (NSCLC). The articles also show that LC is usually the second cancer that appears in the evolution of patients, while our cases had a reverse sequence of appearance of the two cancers, the first being LC.

Conclusions: Physicians should know the most frequent combinations and time intervals of multiple metachronous and synchronous primary cancers in order to make an early detection and to start the most appropriate treatment.

Current occupation/position: scientific researcher, first degree, qualified doctor, primary physician in medical oncology. Teaching career: affiliated with the doctoral school of UMF Carol Davila since 2014. Clinical or research experience: over 30 clinical studies, project director and collaborator in 4 national grants and one international. Original contributions: ● The first phase III study in the world comparing chemotherapy combinations: Gemzar plus carboplatin compared to cisplatin plus vinblastine. - Lung Cancer 2002 ● The first study in Romania on endobronchial brachytherapy associated with chemotherapy - Viasan Contract October 2001, ● The first treaty in Romania on good clinical practice in clinical trials in oncology with international participation. ● The first ESMO-designated Center in Romania for the integration of Medical Oncology with Palliative Care. Titles and distinctions: Scientific researcher, first degree (MECTI order no. 4506, July 22, 2010, Qualified Doctor, UMF Carol Davila, MS Order 2014, Doctor of Medical Sciences UMF Carol Davila 2002, Primary Physician in Medical Oncology, Bronchology Competence (Grant Nantes-France 1993), Palliative Care Competence. ESMO Grant for Palliative Care Switzerland 2008. Institutional and organizational skills: head of the medical oncology section at IOB 2018-2021, head of the oncology department at the C. Davila Clinical Nephrology Hospital, Coordinator of the Bucharest Institute of Oncology (IOB) as the ESMO designated Center for the integration of Medical Oncology with Palliative Care. Editor-in-chief of “Oncologist Hematologist”. Activity and affiliations within scientific organizations, national and international societies: Executive President of the National Society of Medical Oncology 2010-2018, Former Romanian Representative in the Palliative Care Group of the European Society of Medical Oncology (ESMO-Designed Centers), First national ESMO representative (1990-2005), Former national Representative in the International Society of Geriatric Oncology (2008-2018), European Commission Expert in the HORIZON 2020-2025 Oncology Program. Publications mentioned only as number: treatises, monographs, chapters in other reference publications, scientometric indices, citations; 3 chapters in international treatises, 34 chapters in books published in Romania, 2330 citations. Other relevant information: Organizer and lecturer of scientific symposia with the participation of over 60 lecturers from the EU and the USA.