Association between lung cancer and prostate cancer, 3 studied cases, short literature review

Background: The association of lung cancer with prostate cancer is little studied. In the Medscape site we do not have any reference to this association.

Material and method: We have collected data from 3 concrete cases regarding this association and we evaluated their characteristics. On the other hand, we did a literature review trying to do a review related to the particularities of the patients that were based on articles recommended by artificial intelligence (AI). We did not refer to possible genetic determinations, but from the current data, identical genetic modifications for these two types of cancer have not been investigated.

Results: We followed 10 articles selected by AI regarding the association of lung cancer (LC) with prostate cancer (PC). From the analysis of these studies and case presentations we drew several conclusions. Thus, from the articles studied, it emerges that this association is rare. Most authors studied pulmonary metastases of PC and not the association of LC with PC. The articles studied mainly present the metachronous association of PC cancer with (Small Cell Lung Cancer) SCLC, while our case series was represented by cases with Non Small Cell Lung Cancer (NSCLC). The articles also show that LC is usually the second cancer that appears in the evolution of patients, while our cases had a reverse sequence of appearance of the two cancers, the first being LC.

Conclusions: Physicians should know the most frequent combinations and time intervals of multiple metachronous and synchronous primary cancers in order to make an early detection and to start the most appropriate treatment.

Dr. Alexandru Calin Grigorescu, from the Clinical Hospital for Nephrology “Dr. Carol Davila” in Bucharest, Romania, became a specialist in medical oncology in 1991 and was awarded a grant in thoracic oncology in France in 1993. In 2003, he obtained his competence in palliative care and successfully passed the habilitation exam, qualifying him to supervise doctoral research. He received the prestigious ESMO grant in palliative care in 2018 and was awarded the Researcher Degree I (Research Professor) in 2014 at Bucharest UMF “Carol Davila,” confirmed by the Ministry of Health. Dr. Grigorescu serves as a reviewer for Elsevier and is the Editor-in-Chief of the national Romanian journal of oncology, Oncolog Hematolog. In recognition of his significant contributions to the field, he was honored as a member of the Romanian Academy of Medical Sciences in 2022.