Title: Hypoxia-Fibrosis Cycle in Pancreatic Cancer Reveals Potential Pathways Associated with Tumor Progression and Predicts Poor Prognosis

Pancreatic cancer (PC) is difficult to treat and has the lowest five-year survival rate across the world. PC is characterized by desmoplasia composed of abundant cancer-associated fibroblasts (CAFs) and excessive extracellular matrix (ECM), which creates a pathological barrier th [....] » Read More

Title: Personalized and Precision Medicine (PPM) through The View of Biodesign-Inspired Transla-tional Research: An Option for Clinical Oncologists, Caregivers and Consumers to Realize the Potential of Genomics-informed Care to secure the Human Biosafety

A new systems approach to diseased states and wellness result in a new branch in the healthcare services, namely, personalized and precision medicine (PPM). Meanwhile, the era of genomics-based medicine and thus genomics biomarkers promises to provide molecular tests that will pe [....] » Read More

Title: Targeted gene and drug delivery nanosystems to hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is one of the major causes of cancer mortality worldwide, highlighting the urgent need for the development of new therapeutic approaches, such as those involving the combination of gene therapy and chemotherapy, that potentially present higher thera [....] » Read More

Title: Information Leakage: Types, Remedies, and Open problems

Information Leakage threatens and questions the use of machine learning model in real-life clinical applications. In effect, information leakage is similar to vulgar overfitting, yet rather more subtle and even when detected much harder to remove. Some recent research i [....] » Read More

Title: Personalized and Precision Oncology (PPO) to Be Set Up via Precision Oncology Strategy for Can-cer Care Team: Developing Targeted Cancer Therapy & Advancing Personalized Cancer Care

A new systems approach to diseased states and wellness result in a new branch in the healthcare services, namely, personalized and precision medicine (PPM). The concept of PPM is becoming increasingly relevant for cancer treatment, moving from the ‘one-size-fits-all’ [....] » Read More