Title: Targeted nanosystems to mediate combined cancer therapy

Hepatocellular carcinoma (HCC) is one of the major causes of cancer mortality worldwide, highlighting the urgent need for the development of new therapeutic approaches, such as those involving the combination of gene therapy and chemotherapy, that potentially present higher thera [....] » Read More

Title: Information leakage: Types, remedies, and open problems

Information Leakage threatens and questions the use of machine learning model in real-life clinical applications. In effect, information leakage is similar to vulgar overfitting, yet rather more subtle and even when detected much harder to remove. Some recent research i [....] » Read More

Title: Cell viability assays under radiofrequency application modulated by nanomaterials

In this keynote talk, it will be explored the use of the Hill model to assess the Benchmark dose (BMD), the lethal dose 50 (LD50), the cooperativity (E) and the dissociation constant (K) while analyzing cell viability data using nanomaterials. The presentation is addressed to dis [....] » Read More

Title: A novel mRNA genomic technology for precision medicine, cancer diagnosis, prognosis, treatment follow-up

Current screening methods—radiological imaging, DNA-based tests, and pathological assessments—often fail to detect malignancies at early stages. Despite technological advances, gene-based diagnostics specifically designed for early cancer detection remain limited. To [....] » Read More

Title: Resveratrol reduces the presence of Extracellular Traps (ETs) in acute promyelocytic leukemia (NB4) cells

NETosis and ETosis are processes involving the release of extracellular traps (ETs). They have been linked to cancer progression, particularly in promoting metastasis and tumor-associated thrombosis. This indicates that redundant NETs/ETs formation can contribute to cancer spread [....] » Read More

Title: GPER-driven crosstalk in breast cancer: Bridging drugs resistance and tumor microenvironment remodeling

Triple-negative breast cancer (TNBC) is a particularly aggressive type of breast cancer, known for its lack of effective treatments and unfavorable prognosis. The G protein-coupled estrogen receptor (GPER), a novel estrogen receptor, is linked to increased malignancy in various c [....] » Read More

Title: Preclinical study on new parathyroid recognition technology in thyroid surgery

Background: The parathyroid gland is the smallest organ in the organism, with an important function of regulating blood calcium in the human body. The accidental resection of the parathyroid gland during thyroid surgery cannot be ignored, so attention should be paid to the identi [....] » Read More

Title: Global trends and predictive factors of prophylactic mastectomy in women: A systematic review and meta-analysis

IMPORTANCE: The prevalence of prophylactic mastectomy is increasing globally despite the aggressiveness of the surgery and its uncertain effectiveness in preventing cancer.   OBJECTIVE: To estimate the global prevalence of prophylactic mastectomy and assess the [....] » Read More

Title: From experimental research to clinical trial in the treatment of complication of radiotherapy by stem cells

Statement of the problem: The late adverse effects of pelvic radiotherapy concern 5 to 10% of patients, which could be life threatening. However, a clear medical consensus concerning the clinical management of such healthy tissue sequelae does not exist. Our group has demonstrate [....] » Read More

Title: Is artificial intelligence a possible solution for challenges in healthcare?

Introduction: Healthcare systems are facing mounting challenges from aging populations, increasing patient demand, and chronic disease burdens. Conventional approaches are often insufficient, highlighting the need for innovative tools. Artificial intelligence (AI) has emerged [....] » Read More

Title: The regulatory role of endothelial RhoA on tumor microenvironment

The endothelial barrier plays an active role in tumor growth, dissemination and metastasis. For metastasis, the transendothelial migration of the tumor cells is a critical step, however, the endothelial regulatory elements of this step remain obscure. We present data demonstratin [....] » Read More

Title: Applying the concept of "Lean Management": evaluation of a pioneer off-site injection program for androgen deprivation treatment of prostate cancer

Purpose: Due to the large number of prostate cancer patients who require androgen deprivation therapy (ADT), and the frequent monthly administration of a new gonadotropin-releasing hormone (GnRH) antagonist, our province pioneered off-site injection programs in Regina, which is t [....] » Read More

Title: The paradox of spirituality: Its impact on social wellbeing in aya cancer survivors

Background: Cancer survivors often embark on a challenging journey towards physical and emotional recovery, seeking various avenues to enhance their overall well-being. Among these avenues, spirituality has gained recognition as a coping mechanism that provides solace and purpose [....] » Read More

Title: Innovative fiber solutions for cancer diagnostics

The latest innovative fiber solutions to be reviewed for the advanced biomedical applications in 0.3- 16µm range, including multispectral diagnostics to define tumor margins in oncology ex-vivo and in- vivo, plus tumor detection with IR-fiber and Raman endoscopy.   [....] » Read More

Title: Immunotherapy in merkel cell carcinoma of the skin: A 2025 comprehensive review

Purpose: Merkel cell carcinoma (MCC) is a rare and aggressive form of skin cancer. Although immunotherapy has transformed MCC management, published data remains limited. This comprehensive review evaluates current evidence on immunotherapy in MCC. Methods: Peer-reviewed articles [....] » Read More

Title: Application of CRISPR–Cas9 technology in the treatment of chronic lymphocytic leukemia with TP53 mutations

Aim This study proposes the implementation of clustered regularly interspaced short palindromic repeats (CRISPR)–CRISPR-associated protein 9 (Cas9) technology for gene therapy targeting genetic mutations in human lymphocytes affected by chronic lymphocytic leukemia, (CLL [....] » Read More

Title: A narrative review on the roles of nursing in sexual dysfunction among oncological patients with updated recommendations

Background Sexual dysfunction is a prevalent yet often overlooked issue among cancer patients, significantly affecting their quality of life, emotional well-being, and intimate relationships. Despite the high prevalence (87%) of sexual dysfunction among cancer survivors, it r [....] » Read More

Title: Managing sexual issues in melanoma patients: A scoping review

Background Managing sexual issues in melanoma patients involves addressing both physical and psychological changes that may arise during or after treatment. Although melanoma itself may not directly affect sexual function, treatments such as radiotherapy, immunotherapy, targe [....] » Read More

Title: Oncology nurses’ attitudes, knowledge and practices in providing sexuality care to cancer patients: A scoping review

Sexual health in cancer care is often overlooked. This study examines oncology nurses’ knowledge and practices regarding sexuality care, identifying barriers and facilitators. A Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA)-guided search of Sco [....] » Read More

Title: Theory and perspective: Big data and artificial intelligence accelerate the pursuit of a universal cancer principle—opportunities and challenges

Although numerous cancer-associated mechanisms are reported on a daily basis, the establishment of a unifying theoretical framework capable of explaining and ultimately eradicating all cancers remains unresolved. Emerging advances in big data analytics and artificial intelligence [....] » Read More

Title: Instant high-sensitivity non-invasive in-vivo diagnosis during biopsy

Today, doctors have to wait until the tumor grows large enough to become detectable. At this stage, it is often too late to cure. Biopsy, the gold standard in cancer diagnostics, cannot detect tumors in real-time, is often invasive, and frequently misses microscopic-size tumors. [....] » Read More

Title: Beyond survival: The silent struggle of living after cancer

Let me tell you about a woman I loved. She was strong, brave, and relentless. She beat cancer not once, not twice, but three times. From the outside, it looked like victory. Yet her story did not end in celebration. Her third diagnosis took more than her health. It took her abili [....] » Read More

Title: Is cancer theory incomplete?

According to one physicist, major advances in science arise from two sources. The first is the introduction of new data and the second is the study of inconsistencies in established knowledge. Has cancer research missed the boat? Classically, experimental carcinogenesis is a comp [....] » Read More

Title: Strategic development of novel cancer immunotherapies – medical strategy toward regulatory success

Over the past decade checkpoint inhibitors directed against the programmed death ligand 1 (PD-L1) emerged as major therapeutic advance across numerous tumor indications. While immunotherapy with PD-L1 inhibitors achieved durable responses and long-term survival in many patients s [....] » Read More

Title: Extracellular vesicle pathways as regulators of tumor-vascular interactions in glioblastoma

Glioblastoma (GBM), the most prevalent astrocytic brain tumour, remains incurable in spite of decades of research. Florid neovascularization, a morphological hallmark of GBM, is still poorly understood, as is the role of blood vessels in mediating the access of immune cells into [....] » Read More

Title: Anticancer effect of patuletin on neuroblastoma cell line SH-SY5Y

Neuroblastoma is an extracranial solid tumor, usually found in children, and one of the most common pediatric cancers. It originates from the neural crest cells of the sympathetic nervous  system. While multimodal therapies: including chemotherapy, radiotherapy, surgery, and [....] » Read More

Title: Cardiac coherence: A new approach to oncology medicine

In the oncology clinic, the issue of anguish, stress and anxiety is a very important part of treatment. These affects can also condition the outcome of treatment, as well as patients' experiences of their disease. Cancer has specific psychological repercussions compared with [....] » Read More

Title: Time and cost to healthcare providers and sites associated with preparation and administration of subcutaneous vs intravenous nivolumab for the treatment of cancer: a time-driven activity-based costing study

Background: Subcutaneous (SC) administration of oncology therapies offers increased convenience for patients and healthcare providers (HCPs) and reduced administration costs when compared with intravenous (IV) delivery. SC nivolumab (NIVO), in combination with hyaluronidase-nvhy [....] » Read More

Title: Intelligent oncology: The transformative role of AI in the future of cancer research and care

Artificial Intelligence (AI) is poised to revolutionize oncology by transforming how we detect, understand, and treat cancer. As cancer remains a leading cause of death globally, integrating AI into research and clinical workflows offers unprecedented opportunities to address its [....] » Read More

Title: Targeting alternative lengthening of telomeres in cancer

Telomeres have a double role in neoplasia. These highly conserved repetitive nucleoprotein structures that protect the ends of chromosomes safeguard somatic cells from tumorigenic mutations and prevent cancer. However, most tumors bypass replicative senescence and support maligna [....] » Read More

Title: Association between lung cancer and prostate cancer, 3 studied cases, short literature review

Background: The association of lung cancer with prostate cancer is little studied. In the Medscape site we do not have any reference to this association.   Material and method: We have collected data from 3 concrete cases regarding this association and we evaluated the [....] » Read More

Title: An Eternal Moment (A Patient's Feedback to Medical Care Givers)

Purpose/Objective(s): Narrative Oncology can describe relevant components of a patient and health care staff interaction in a complimentary way. Fictitious microstories can provide such critical information in a concise way and respect the anonymity both of health care staff a [....] » Read More

Title: Dr Nicola Sarandria’s Theory of Arginase-1 and N2 neutrophil’s Role in Rectal Cancer based on the 2025 OR1 Research Study directed by Dr Nicola Sarandria: New insights on the relationship between Arginase-1, Tumor Associated Neutrophils, Perineural Invasion, Neoadjuvant therapy and Prognosis in Rectal Cancer Patients

Introduction Rectal cancer is one of the most common cancers with a high epidemiologic burden. Need for new prognostic and predictive indicators and therapies is urgent in the field to improve clinical outcomes and gather a better understanding of the disease. Indicators such [....] » Read More

Title: The power of trust through the eyes of a patient

One of the first things to be impacted when a patient receives a cancer diagnosis is Trust. Trust in their body, in the world as they see it and very quickly they need to learn to build trust in their clinicians and the proposed pathways to tackle one of the toughest experiences [....] » Read More

Title: Daily profile in miRNA expression in the colon and their role in colorectal cancer

Colorectal cancer (CRC) belongs among the most frequently diagnosed malignancies and its progression is strongly influenced by miRNAs as well as the circadian system. With the use of high-throughput sequencing of miRNAs expressed in the rat colon during 24h light (L) dark (D) cyc [....] » Read More

Title: Expanding the reach: Integrating AI-generated auto contours via deep learning segmentation into diverse treatment planning systems

Aim: Contouring in treatment planning systems for radiation oncology plays a crucial role in ensuring accurate and effective treatment. The integration of AI-generated auto-contouring with other planning systems, particularly in remote areas, is essential for achieving optimal co [....] » Read More

Title: Comprehensive pharmacokinetic profiling and molecular docking analysis of natural bioactive compounds targeting oncogenic biomarkers in breast cancer

Breast cancer remains a leading cause of mortality in women worldwide, emphasizing the need for novel, safe, and effective therapeutic strategies. This study investigates the potential of four natural bioactive compounds—Berberine, Curcumin, Withaferin A, and Ellagic Acid&m [....] » Read More

Title: Nanoparticle-based therapeutic platforms: Development and evaluation for cancer treatment

Polymeric nanoparticles are widely explored for drug delivery, though challenges remain in drug loading, entrapment, and release. In this study, starch nanoparticles were prepared from unripe banana fruit, which contains amylose (26–28%) and amylopectin (72–74%). Amyl [....] » Read More

Title: Difficult-to-manage prostate cancer scenarios illustrating the pathologist’s role: Two case reports

Background: Prostate cancer remains one of the most common malignancies among men worldwide, and its diagnosis and management rely fundamentally on accurate histopathologic evaluation. Gleason grading, now incorporated into the ISUP Grade Group system, is central to determining [....] » Read More

Title: Overview of PSMA PET and salvage treatment of previously irradiated recurrent prostate cancers

Background: Prostate cancer is prevalent in the United States and often spotlighted due to celebrity diagnoses. Recurrent prostate cancer remains a major clinical challenge, typically first indicated by a rising prostate-specific antigen (PSA) level. PSA serves as a reliable b [....] » Read More

Title: Updates on prostate cancer

Background: Prostate cancer remains one of the most prevalent malignancies in men, significantly contributing to global morbidity, mortality, and healthcare costs. Advances in diagnostics and treatment over the past decade have reshaped management strategies. Methods: A lite [....] » Read More

Title: Improving quality of life among cancer patients in the modern era

Introduction: Modern cancer treatments often lead to a wide range of acute side effects, such as nausea, fatigue, pain, and infections that significantly impair daily functioning. Long-term complications, including neuropathy, hormonal imbalances, infertility, and emotional di [....] » Read More

Title: Synergistic antitumor effects of 2NF and safingol combination in breast cancer: Molecular mechanisms involving SPHK1, MAPKs, and ER stress

Background The sphingosine kinase 1 (SphK1)/sphingosine-1-phosphate (S1P) axis has been widely studied in cancer research due to its role in modulating sphingolipid metabolism, which determines cell survival or death. Furthermore, SphK1 inhibitors prevent catabolism of ceram [....] » Read More

Title: Analysis of 64 cases of oral squamous cell carcinoma of the buccal mucosa

Introduction: Squamous cell carcinoma of the buccal mucosa is the most common oral cavity cancer in Southeast Asia. In India, 60 to 80% of oral squamous cell carcinoma cases present with advanced stage as compared to 40% in developed countries. Carcinoma of the buccal mucosa is t [....] » Read More

Title: A new tension-sensitive signaling pathway involving polymerization of actin prevents chromatin bridge breakage in cytokinesis in human cancer cells

Chromatin bridges are strands of incompletely segregated DNA connecting the anaphase poles or daughter nuclei. Chromatin bridges can arise from incompletely replicated DNA, defective resolution of DNA catenates or dicentric chromosomes which are formed by chromosome fusions. If u [....] » Read More

Title: How can developing countries improve survival rates of glioma patients

Background: Gliomas represent one of the most challenging brain malignancies with historically poor survival outcomes, particularly in developing countries where healthcare infrastructure limitations significantly impact patient care and treatment accessibility. Our objective is [....] » Read More

Title: Updates on CNS tumors

Background: Central nervous system (CNS) tumors are categorized as primary or secondary, with metastatic tumors being more common. They contribute significantly to morbidity and mortality. Over the past decade, notable advances have emerged in their management. Methods: [....] » Read More

Title: The transcriptional regulator PRDM1: Key insights into its role in NK cell homeostasis and malignancy

Natural killer cell lymphoma (NKCL) is an aggressive type of cancer with poor prognosis. As a rare cancer type with geographic predilection, it was of utmost significance to identify the cancer- associated genes contributing to development of NKCL. Our previous study revealed rec [....] » Read More

Title: Oncologic emergencies – a narrative review with expert opinions and latest recommendations

Introduction: Oncologic emergencies are some of the most critical and time-sensitive situations clinicians can face in cancer care. These events, ranging from metabolic imbalances to spinal cord compression or life-threatening infections, can progress rapidly and require immed [....] » Read More

Title: Improving survival rates of glioma patients in developing countries

Background: Gliomas represent one of the most challenging brain malignancies with historically poor survival outcomes, particularly in developing countries where healthcare infrastructure limitations significantly impact patient care and treatment accessibility.   Obje [....] » Read More

Title: Well differentiated liposarcoma of face: An unusual case report

Background:  Liposarcoma’s are rarely reported in the head and neck region. The lacking literature evidence of this particular entity makes the clinical identification and treatment decision very challenging. Here we present a case of liposarcoma in a 95 year old femal [....] » Read More

Title: Investigating the combined effects of paclitaxel and pirfenidone on metastasis in triple-negative breast cancer (TNBC) cells

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by the absence of estrogen receptor, progesterone receptor, and HER2 expression, making it unresponsive to conventional hormonal therapies. TNBC is associated with poor prognosis, rapid recurrence, a [....] » Read More

Title: Colorectal cancer screening

Introduction: Colorectal cancer is one of the leading causes of cancer-related mortality worldwide. In many cases, diagnosis occurs at late stages, which negatively affects survival outcomes. Due to its slow progression through precancerous lesions, CRC is particularly amenable t [....] » Read More