Title: A novel mRNA genomic technology for precision medicine, cancer diagnosis, prognosis, treatment follow-up

To be updated shortly...

Title: Personalized and Precision Medicine (PPM) through the view of biodesign-inspired translational research: An option for clinical oncologists, caregivers and consumers to realize the potential of genomics-informed care to secure the human biosafety

A new systems approach to diseased states and wellness result in a new branch in the healthcare services, namely, personalized and precision medicine (PPM). Meanwhile, the era of genomics-based medicine and thus genomics biomarkers promises to provide molecular tests that will pe [....] » Read More

Title: Hypoxia-Fibrosis cycle in pancreatic cancer reveals potential pathways associated with tumor progression and predicts poor prognosis

Pancreatic cancer (PC) is difficult to treat and has the lowest five-year survival rate across the world. PC is characterized by desmoplasia composed of abundant cancer-associated fibroblasts (CAFs) and excessive extracellular matrix (ECM), which creates a pathological barrier th [....] » Read More

Title: Anti-Cancer nanomedicine in humans: 30,000 successful cases and counting

This presentation will cover a close to 30 year journey researching and commercializing nanotechnology for improving disease prevention, diagnosis, and treatment (including cancer) which has led to numerous products including nano spinal implants now in over 30,000 patients to da [....] » Read More

Title: Targeted gene and drug delivery nanosystems to hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is one of the major causes of cancer mortality worldwide, highlighting the urgent need for the development of new therapeutic approaches, such as those involving the combination of gene therapy and chemotherapy, that potentially present higher thera [....] » Read More

Title: Information leakage: Types, remedies, and open problems

Information Leakage threatens and questions the use of machine learning model in real-life clinical applications. In effect, information leakage is similar to vulgar overfitting, yet rather more subtle and even when detected much harder to remove. Some recent research i [....] » Read More

Title: Personalized and Precision Oncology (PPO) to be set up via precision oncology strategy for cancer care team: Developing targeted cancer therapy & advancing personalized cancer care

A new systems approach to diseased states and wellness result in a new branch in the healthcare services, namely, personalized and precision medicine (PPM). The concept of PPM is becoming increasingly relevant for cancer treatment, moving from the ‘one-size-fits-all’ [....] » Read More

Title: Artificial intelligence (AI) and the examination of the cornea at the slit lamp

The slit lamp is an obligatory instrument for every ophthalmologist. It was invented by Alvar Gullstrand in 1910. Over the following decades, the slit lamp has been supplemented by additional applications such as the three-mirror contact lens and the magnifying glass, the applana [....] » Read More

Title: Lactate dehydrogenase B noncanonically promotes ferroptosis defense in KRAS-driven lung cancer

Ferroptosis is an oxidative, non-apoptotic form of cell death that is frequently inactivated in cancer, yet its regulation in oncogene-specific tumors remains poorly understood. Here, we identify lactate dehydrogenase B (LDHB)—but not the closely related LDHA—as a non [....] » Read More

Title: Single-Cell and spatial profiling of immune and tumor- Intrinsic mechanisms in response to neoadjuvant radiotherapy plus immunochemotherapy in microsatellite stable locally advanced rectal cancer

Background: Locally advanced rectal cancer (LARC) is recognized as a highly aggressive disease, characterized by frequent local recurrence and metastasis. Unlike microsatellite instability-high (MSI-H) tumors, microsatellite stable (MSS) LARC is immunologically cold and poorly re [....] » Read More

Title: Extracellular vesicle pathways as regulators of tumor-vascular interactions in glioblastoma

Glioblastoma (GBM), the most prevalent astrocytic brain tumour, remains incurable in spite of decades of research. Florid neovascularization, a morphological hallmark of GBM, is still poorly understood, as is the role of blood vessels in mediating the access of immune cells into [....] » Read More

Title: Targeting telomerase for its advent in cancer therapeutics

Telomerase has emerged as an important primary target in anticancer therapy. It is a distinctive reverse transcriptase enzyme, which extends the length of telomere at the 3′ chromosomal end, and uses telomerase reverse transcriptase (TERT) and telomerase RNA templatecontain [....] » Read More

Title: GPER-driven crosstalk in breast cancer: Bridging drugs resistance and tumor microenvironment remodeling

Triple-negative breast cancer (TNBC) is a particularly aggressive type of breast cancer, known for its lack of effective treatments and unfavorable prognosis. The G protein-coupled estrogen receptor (GPER), a novel estrogen receptor, is linked to increased malignancy in various c [....] » Read More

Title: Dietary carcinogens and cancer risk: Knowledge, awareness, and perception of Cameroonians

Background: Food, while essential for health, can pose risks when contaminated or adulterated with harmful substances, some of which are carcinogenic. Cancer, one of the leading global causes of death, continues to rise, with an estimated 28.4 million new cases projected by 2040, [....] » Read More

Title: Vascular endothelial growth factor and colorectal cancer risk: A two sample mendelian randomization analysis

Numerous clinical studies have found that high expression of Vascular Endothelial Growth Factor (VEGF) is closely associated with poor prognosis in Colorectal Cancer (CRC), including high tumor recurrence rates and short survival periods. However, observational studies are prone [....] » Read More

Title: Rare bone metastasis of neuroendocrine tumors of unknown origin: A case report and literature review

Background: Neuroendocrine tumors (NETs) are rare neoplasms, accounting for approximately 0.5% of all tumors, and are characterized by their potential to metastasize to the liver, lymph nodes, and bones. Bone metastases from NETs are uncommon, and cases with unknown primary orig [....] » Read More